| Date | Opponent | Location | Tournament |
|---|---|---|---|
| 11/23/2021 | Novinger | Novinger | |
| 11/29/2021 | Putnam County | Schuyler County | Tri-Rivers |
| 12/1/2021 | Scotland County | Schuyler County | Tri-Rivers |
| 12/4/2021 | North Shelby | Schuyler County | Tri-Rivers |
| 12/7/2021 | Brookfield | Brookfield | |
| 12/10/2021 | Knox County | Knox County | |
| 12/14/2021 | Polo* | Milan | |
| 12/21/2021 | Atlanta | Milan | |
| 12/28/2021 | Chillicothe | Trenton (NCMC) | |
| 12/31/2021 | Mid-Buchanan | Kansas City (Hy-Vee Arena) | |
| 1/3/2022 | Maysville* | Milan | |
| 1/4/2022 | Princeton* | Princeton | |
| 1/7/2022 | Putnam County* | Putnam County | |
| 1/10/2022 | Brookfield | Milan | Milan |
| 1/12/2022 | Novinger | Milan | Milan |
| 1/18/2022 | South Harrison* | Milan | |
| 1/24/2022 | Marceline | Marceline | |
| 1/27/2022 | St. Charles | Lebanon | Lebanon |
| 1/28/2022 | Lebanon | Lebanon | Lebanon |
| 1/29/2022 | Joplin | Lebanon | Lebanon |
| 1/31/2022 | Marceline | Milan | Milan |
| 2/1/2022 | Gallatin* | Milan | |
| 2/4/2022 | SJCS | Milan | |
| 2/8/2022 | Trenton* | Trenton | |
| 2/12/2022 | SJCS | Milan | |
| 2/18/2022 | Scotland County | Scotland County | |
| 2/22/2022 | South Harrison | Trenton (NCMC) | Districts |
| 2/25/2022 | Trenton | Trenton (NCMC) | Districts |
| 3/2/2022 | East Buchanan | Kirksville (TSU) | State |