| Date | Opponent | Location | Playoffs |
|---|---|---|---|
| 8/27/2021 | Highland | Putnam County | |
| 9/3/2021 | Father Tolton | Putnam County | |
| 9/10/2021 | Milan* | Milan | |
| 9/17/2021 | Trenton* | Trenton | |
| 9/24/2021 | Princeton* | Putnam County | |
| 10/1/2021 | South Harrison* | South Harrison | |
| 10/8/2021 | Gallatin* | Putnam County | |
| 10/15/2021 | Maysville* | Maysville | |
| 10/22/2021 | Polo* | Putnam County | |
| 10/29/2021 | Gallatin | Gallatin | Districts |