| Date | Opponent | W/L | Score | Opp Score | Location | Tournament |
|---|---|---|---|---|---|---|
| 11/23/2021 | Novinger | L | 53 | 56 | Novinger | |
| 11/29/2021 | Putnam County | L | 56 | 77 | Schuyler County | Tri-Rivers |
| 12/1/2021 | Clark County | W | 49 | 39 | Schuyler County | Tri-Rivers |
| 12/4/2021 | Schuyler County | W | 57 | 48 | Schuyler County | Tri-Rivers |
| 12/7/2021 | Brookfield | W | 43 | 38 | Brookfield | |
| 12/10/2021 | Knox County | W | 44 | 41 | Knox County | |
| 12/11/2021 | North Andrew | L | 54 | 63 | Benton | |
| 12/14/2021 | Polo* | W | 48 | 33 | Milan | |
| 12/21/2021 | Atlanta | W | 54 | 50 | Milan | |
| 12/27/2021 | Norborne | W | 62 | 31 | Trenton (NCMC) | |
| 12/31/2021 | Mid-Buchanan | L | 37 | 53 | Kansas City (Hy-Vee Arena) | |
| 1/3/2022 | Maysville* | L | 45 | 52 | Milan | |
| 1/4/2022 | Princeton* | W | 56 | 31 | Princeton | |
| 1/7/2022 | Putnam County* | L | 53 | 59 | Putnam County | |
| 1/11/2022 | Linn County | W | 63 | 34 | Milan | Milan |
| 1/13/2022 | Novinger | W | 40 | 34 | Milan | Milan |
| 1/17/2022 | Hamilton | W | 54 | 49 | Hamilton | |
| 1/18/2022 | South Harrison* | W | 37 | 34 | Milan | |
| 1/24/2022 | Marceline | W | 59 | 43 | Marceline | |
| 1/28/2022 | South Shelby | L | 53 | 58 | Milan | |
| 1/31/2022 | Marceline | W | 49 | 36 | Milan | Milan |
| 2/1/2022 | Gallatin* | L | 39 | 57 | Milan | |
| 2/4/2022 | SJCS | W | 47 | 41 | Milan | |
| 2/8/2022 | Trenton* | W | 59 | 32 | Trenton | |
| 2/12/2022 | Albany | W | 48 | 47 | Milan | |
| 2/18/2022 | Scotland County | W | 57 | 42 | Scotland County | |
| 2/24/2022 | Hamilton | W | 43 | 30 | Trenton (NCMC) | Districts |
| 2/26/2022 | Marceline | W | 47 | 44 | Trenton (NCMC) | Districts |
| 3/2/2022 | Mid-Buchanan | L | 33 | 49 | Kirksville (TSU) | State |