| Date | Opponent | W/L | Score | Opp Score | Location | Tournament |
|---|---|---|---|---|---|---|
| 11/23/2021 | Novinger | W | 72 | 52 | Novinger | |
| 11/29/2021 | Putnam County | W | 45 | 41 | Schuyler County | Tri-Rivers |
| 12/1/2021 | Scotland County | L | 53 | 58 | Schuyler County | Tri-Rivers |
| 12/4/2021 | North Shelby | W | 54 | 47 | Schuyler County | Tri-Rivers |
| 12/7/2021 | Brookfield | W | 62 | 29 | Brookfield | |
| 12/10/2021 | Knox County | W | 70 | 39 | Knox County | |
| 12/14/2021 | Polo* | W | 44 | 36 | Milan | |
| 12/21/2021 | Atlanta | W | 53 | 43 | Milan | |
| 12/28/2021 | Chillicothe | L | 54 | 64 | Trenton (NCMC) | |
| 12/31/2021 | Mid-Buchanan | W | 56 | 37 | Kansas City (Hy-Vee Arena) | |
| 1/3/2022 | Maysville* | W | 65 | 31 | Milan | |
| 1/4/2022 | Princeton* | W | 59 | 43 | Princeton | |
| 1/7/2022 | Putnam County* | W | 57 | 24 | Putnam County | |
| 1/10/2022 | Brookfield | W | 52 | 38 | Milan | Milan |
| 1/12/2022 | Novinger | W | 69 | 29 | Milan | Milan |
| 1/18/2022 | South Harrison* | W | 72 | 58 | Milan | |
| 1/24/2022 | Marceline | W | 55 | 41 | Marceline | |
| 1/27/2022 | St. Charles | W | 66 | 39 | Lebanon | Lebanon |
| 1/28/2022 | Lebanon | L | 44 | 98 | Lebanon | Lebanon |
| 1/29/2022 | Joplin | L | 21 | 64 | Lebanon | Lebanon |
| 1/31/2022 | Marceline | W | 53 | 36 | Milan | Milan |
| 2/1/2022 | Gallatin* | W | 63 | 20 | Milan | |
| 2/4/2022 | SJCS | L | 44 | 76 | Milan | |
| 2/8/2022 | Trenton* | W | 32 | 31 | Trenton | |
| 2/12/2022 | SJCS | W | 70 | 63 | Milan | |
| 2/18/2022 | Scotland County | L | 49 | 60 | Scotland County | |
| 2/22/2022 | South Harrison | W | 60 | 46 | Trenton (NCMC) | Districts |
| 2/25/2022 | Trenton | W | 52 | 44 | Trenton (NCMC) | Districts |
| 3/2/2022 | East Buchanan | L | 34 | 38 | Kirksville (TSU) | State |