| Date | Opponent | Location | Playoffs |
|---|---|---|---|
| 8/27/2021 | Bishop LeBlond | Bishop LeBlond | |
| 9/3/2021 | Schuyler County | Pattonsburg | |
| 9/10/2021 | North Andrew* | North Andrew | |
| 9/17/2021 | King City* | Pattonsburg | |
| 9/24/2021 | Stanberry* | Pattonsburg | |
| 10/1/2021 | Rich Hill | Rich Hill | |
| 10/8/2021 | Worth County* | Pattonsburg | |
| 10/15/2021 | SJCS | Pattonsburg | |
| 10/22/2021 | Albany* | Albany |